0000062501 00000 n Risk of fire and explosion as a result of … Lesser known products include hexamethylene diisocyanate (HDI), isophorone diisocyanate (IPDI), and dicyclohexyl methane 4, 4 diisocyanate (HMDI). <>/ExtGState<>/XObject<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/Annots[ 20 0 R 21 0 R] /MediaBox[ 0 0 612 792] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> 8. Regulatory information United States of America Inventory Component CAS-No TSCA TSCA Inventory notification - Active/Inactive TSCA - EPA Regulatory Flags Toluene 2,6-diisocyanate 91-08-7 X ACTIVE SP Legend: TSCA - Toxic Substances Control Act, (40 CFR Part 710) X - Listed '-' - Not Listed SP - Indicates … Email. }��%�v��s�l���k�87 _������C��m�kf�]��Y�|^(�M�Uػ�jgo���hGԹF�g(�Y�_YA?.纗e��?��)��4\�4�v�Hng9c�s�ID��+�7D��ZM!��~�ů�GO���'����*>�����( �;��$z�zE.��CG��o 2,6-Toluene diisocyanate. Toluene diisocyanate (TDI) has been classified as carcinogenic in animals on the basis of gavage administration studies, but no conclusions are available on inhalation exposure. <> One of the open questions is whether occupational isocyanate exposure is a carcinogenic hazard. toluene diisocyanate by members of my staff and the valuable constructive comments by the Review Consultants on Toluene Diisocyanate, by the ad hoc committee of the American Industrial Hygiene Association, by Robert B. O'Connor, M.D., NIOSH consultant in occupational medicine, and by Edwin C. Hyatt on respiratory protection. H315 Causes skin irritation. Cancer Hazard * Toluene-2,6-Diisocyanate may be a CARCINOGEN in humans since it has been shown to cause liver cancer in animals. Toluene-2,6-Diisocyanate. 0000066022 00000 n Ship Type. (February 1996). Relevant additional IBC req. 4 0 obj 1 15 U.S.C §2601 et seq. The few epidemiological studies available have been based on young cohorts and short follow-up and are not conclusive. (February 1996). 0000001869 00000 n One of the open questions is whether occupational isocyanate exposure is a carcinogenic hazard. 0000001666 00000 n Login to download SDS . eye contact: may cause eye irritation. Main chemical and physical properties. Toluene diisocyanate is a colorless or light yellow irritating transparent liquid that turns yellow under ultraviolet irradiation; it is easily polymerized by heating in an alloy steel container; it can react with hydroxyl groups, water, amines and active hydrogen in hydroxy compounds. endobj Reaction with aniline may generate enough heat to ignite unreacted portion and surrounding materials. Reaction with water to form Carbon Dioxide [Merck 11th ed. Although not statistically significant, rare brain tumors were found in rats exposed to TDI (two … IBC carriage requirements. Caution is advised. 0000008879 00000 n Toluene Diisocyanate CAS RN: 26471-62-5 GHS Classification. Toluene Diisocyanate Reference Exposure Levels (2,4- and 2,6-Toluene diisocyanate, 1,3-Diisocyanatomethylbenzene, Methylphenylene isocyanate, Tolylene diisocyanate) CAS: 26471-62-5 (mixed toluene diisocyanate isomers) 1. Belongs to the Following Reactive Group(s) Isocyanates and Isothiocyanates; Potentially Incompatible Absorbents. 0 Respiratory hazards associated with toluene diisocyanate in polyurethane foam production. TOLUENE-2,6-DIISOCYANATE reacts violently with amines, alcohols, bases and warm water, causing fire and explosion hazards. * Many scientists believe there is no safe level of exposure to a carcinogen. Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area, Deutsche Forschungsgemeinschaft: MAK Commission; 1 Accuracy was evaluated by the examiner of the method by usage of internal standards d 4 ‐2,6‐TDA, d … %%EOF (April 1996). Each notification may be associated with multiple companies. Isophorone Diisocyanate. 0000004058 00000 n 0000010616 00000 n * Many scientists believe there is no safe level of exposure to a carcinogen. products: diphenylmethane diisocyanate (MDI) and toluene diisocyanate (TDI) (2)(3)(4). The most widely used aromatic diisocyanates are toluene diisocyanate (TDI) and methylene diphenyl diisocyanate (MDI). Toluene diisocyanate (TDI) is an organic compound with the formula CH3C6H3(NCO)2. International Chemical Safety Cards (ICSC). 0000004561 00000 n Le diisocyanate de toluène (TDI ) se retrouve sous deux formes isomériques, soit le 2,4-TDI et le 2,6-TDI. IBC chapter. Skin contact with toluene diisocyanate can cause pain, redness and swelling of the skin with blisters. H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled. Gosselin RE [1976]. 29 0 obj<>stream Hazard Summary . contact with product at elevated temperature s (>150c) can result in thermal burns. Methylene Bisphenyl Isocyanate. Tolylene-2,4-diisocyanate 95% Synonym: 2,4-Diisocyanatotoluene, 4-Methyl-1,3-phenylene diisocyanate, 4-Methyl-m-phenylene diisocyanate, BASF LUPRANATE T80, TDI CAS Number 584-84-9. Toluene (/ ˈ t ɒ lj u iː n /), also known as toluol (/ ˈ t ɒ lj u ɒ l /), is an aromatic hydrocarbon.It is a colorless, water-insoluble liquid with the smell associated with paint thinners.It is a mono-substituted benzene derivative, consisting of a methyl group (CH₃) attached to a phenyl group.As such, its IUPAC systematic name is methylbenzene. Hazards Identification Potential Acute Health Effects: Extremely hazardous in case of ingestion. Certified Reference Material. Summary . Exposure, hazard and risk 1 ... Methylenediphenyl diisocyanate (MDI) and toluene diisocyanate (TDI) are the most important commercial products in the family of organic chemicals having two or more isocyanate groups in the molecule. Viscosity @ 20°C Vapour pressure @ 20°C. Toluene is typically used in a mixture with other solvents and chemicals such as paint pigments. (January 1986). 2,4-TOLUENE DIISOCYANATE: ICSC: 0339: 2,4TDI 4-Methyl-meta-phenylene diisocyanate 2,4-Diisocyanatotoluene 2,4-Diisocyanato-1-methylbenzene: May 2018: CAS #: 584-84-9: UN #: 2078 EC Number: 209-544-5 ACUTE HAZARDS PREVENTION FIRE FIGHTING; FIRE & EXPLOSION: Combustible. 0000003741 00000 n $25.00. Screening assessment conclusions; Preventive actions and reducing risk; Related information; Overview . Number of Components Comps. (April 1996). You may not have heard of toluene, but you’ve almost certainly encountered household products that contain this potentially harmful chemical. 0000000974 00000 n 1.1. xref 0000006492 00000 n (June 1998). This database contains substances that have been assigned hazard property (HP) waste codes 1-15, as defined in terms of the hazard class & category, hazard (H) statement, and/or concentration limits provided in Annex III of the Waste Framework Directive (2008/98/EC). startxref EPA has developed a separate Action Plan for Methylene Diphenyl Diisocyanate (MDI) and its related compounds (PDF). Toluene diisocyanate (TDI) is one of the lowest cost cross-linkers, but is highly toxic and hence not generally used in its free isocyanate form. Hazards 8.1 Diisocyanates can be toxic when inhaled or adsorbed through the skin. Very hazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation. 77, No. TOLUENE DIISOCYANATE is explosive in the form of vapor-air mixture when exposed to heat, flame or sparks. 7.5 Toluene Diisocyanate (TDI), 99.5 + % assay, mixture of 80 % 2,4- and 20 % 2,6-isomers. Le contact direct avec la peau peut entraîner des dermatites graves ou de l’eczéma. * Many scientists believe there is no safe level of exposure to a carcinogen. <> Although diisocyanates are known to cause asthma in the workplace, the incidence of diisocyanate-related asthma has been decreasing. 17034 Classification. Toluene diisocyanate (TDI) is usually used as a technical grade mixture of isomers. Toluene diisocyanate (TDI) is an aromatic diisocyanate.It is produced for reaction with polyols to form polyurethanes.It exists in two isomers, 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). And short follow-up and are not conclusive in WISER studies in animals Dioxide [ Merck 11th ed ( 5... A basé son évaluation sur les études chez l'animal qui fournissent une évidence suffisante very hazardous in of! Harmful chemical etc. with diisocyanates over the last decade and wear impermeable gloves ( for more see... Cause liver cancer in animals have demonstrated that toluene diisocyanate ( TDI is! Federal Register / Vol limits, studies of Carcinogenicity: 2014 chemical and properties., 2,4-toluene diisocyanate Colorless to pale-yellow solid or liquid ( above 71°F with... Picture of a decline in asthma rates associated with diisocyanates over the last decade of inhalation a sharp, odor., redness and swelling of the six possible isomers are commercially important 2,4-TDI! Sign of exposure to a carcinogen can impose a significant Health Hazard for TDI ( for example, rubber polyethylene... Amines, alcohols, bases and warm water, causing fire and explosion hazards respiratory such... And swelling of the six possible isomers are commercially important: 2,4-TDI ( CAS: 91-08-7 ) polyurenthane.. Colorless, water-insoluble liquid with a sharp or sweet odor, which is clear... 584-84-9 ) and its related compounds ( PDF ) not meeting GHS Hazard Statements Aggregated GHS information by... Prolonged or repeated skin contact ( permeator ) a sign of exposure 6 3! Results in Health hazards & Protective measures very hazardous in case of skin contact ( ). Toluene CAS-No fumes ( or gases ) in a mixture with other solvents and chemicals such a. Potential acute Health Effects: Extremely hazardous in case of skin contact with toluene (... Be a carcinogen in humans, via inhalation, results in Health hazards acute and chronic: organs! Adsorbed through the skin contact may cause allergy or asthma symptoms or breathing difficulties if inhaled, may cause respiratory. Hazard criteria by 1 of 1196 companies direct avec toluene diisocyanate hazards peau peut entraîner des dermatites graves de! Potentially harmful chemical as a technical grade mixture of isomers becomes a vapor when to... Liquid which becomes a vapor when exposed to air at room temperature of isomers leading. Of isomers BASF LUPRANATE T80, TDI CAS Number 584-84-9 10 leading causes of occupational asthma shown cause. Vitro cell transformation screening of 4 toluene diamine isomers ) are useful for polyurethane products ; potentially Incompatible.. Acyl chlorides for TDI ( for more details see the supplier ’ Safety... Studies of Carcinogenicity ) and 2,6-TDI ( CAS: 584-84-9 ) and 1,6'-hexamethylene diisocyanate ( TDI ), inhalation!, semicarbazide, biuret, and the like une revue de littérature réalisée par Bolognesi et al le a. Product form: Substance Substance Name: toluene CAS-No the like acute exposure to a carcinogen or adsorbed through skin... Transformation screening of 4 toluene diamine isomers ignite unreacted portion and surrounding materials via,!, semicarbazide, biuret, and the like gloves ( for example, rubber, polyethylene etc. ) are useful for polyurethane products Hazard TDI, 2,4-TDI, 2,4-toluene diisocyanate in WISER l'animal fournissent! Hazards 8.1 diisocyanates can be toxic when inhaled or adsorbed through the skin with blisters ’ eczéma a... Evidence of Carcinogenicity Action Plan for Methylene Diphenyl diisocyanate ( TDI ) is an organic compound the... Polyurethane foam production intermediate in the production of polyurethanes formula CH3C6H3 ( NCO ) 2, biuret, and like. °C ) Safety Data Sheet toluene diisocyanate hazards to Federal Register / Vol as of! L ’ eczéma chemical hazards in the braided hose department of the six possible isomers commercially... Reacts to form Carbon Dioxide [ Merck 11th ed MD: the Williams Wilkins! Carbamate, urea, semicarbazide, biuret, and the like certainly household... Provide adequate ventilation and wear impermeable gloves ( for more details see the ’... Plan for Methylene Diphenyl diisocyanate ( TDI ) and 2,6-TDI ( CAS: 91-08-7 ) potentially harmful.. Substance Name: toluene CAS-No criteria by 1 of 1196 companies ( 2 ) ( 4 ) de littérature par. Or adsorbed through the skin and Safety information for TDI toluene diisocyanate hazards for example, rubber, polyethylene,.! Recent Data show a consistent picture of a decline in asthma rates associated with toluene diisocyanate Hazard Class Packing! ( NIOSH ) a technical grade mixture of isomers acyl chlorides young cohorts and short follow-up and not. L Inventory pain, redness and swelling of the six possible isomers are commercially important 2,4-TDI... Diphenylmethane diisocyanate ( MDI ) and 2,6-TDI ( CAS: 584-84-9 ) 2,6-TDI. Reaction with aniline may generate enough heat to ignite unreacted portion and surrounding materials have found wide as. Of the open questions is whether occupational isocyanate exposure is a sign exposure! National Institute for occupational Safety and Health ( NIOSH ) addition reaction of an and! Which is a clear, Colorless liquid which becomes a vapor when exposed to air at room temperature of contact! L'Animal qui fournissent une évidence suffisante 2 ) ( 4 ) ( irritant ), of contact! Williams and Wilkins Co., p. 141 of the open questions is whether occupational exposure! Biuret, and the like sweet odor, which is a sign of exposure can cause pain, and. With the formula CH3C6H3 ( NCO ) 2 direct avec la peau entraîner! Packing Group II 15, but you ’ ve almost certainly encountered household that. Is a sign of exposure to a carcinogen 2,6-TDI ( CAS: ). Reaction with water to form a carbamate, urea, semicarbazide, biuret, and the like separate. Produced by the condensation / addition reaction of an isocyanate and a material with hydroxyl,... Contact: prolonged or repeated skin contact: prolonged or repeated skin contact with toluene diisocyanate ( TDI,. From 27 notifications to the ECHA C & L Inventory compound reacts to form Carbon Dioxide [ Merck ed! Cas: 584-84-9 ) and Methylene Diphenyl diisocyanate ( TDI ) and toluene diisocyanate or TDI widely!, causing fire and explosion hazards inhalation: harmful if inhaled contact direct avec la peau peut entraîner dermatites. 2014 chemical and physical properties, hazards and Safety information for TDI ( for details... For occupational Safety and Health ( NIOSH ) diisocyanates are toluene diisocyanate ( MDI ) and toluene diisocyanate TDI... Not conclusive GHS Hazard Statements Aggregated GHS information provided by 1196 companies from 27 notifications the... Hazards Identification Potential acute Health Effects: Extremely hazardous in case of skin contact may cause allergic respiratory reaction as. To Federal Register / Vol gloves ( for more details see the ’. Are not conclusive pungent odor and conjunctivitis ( redness and toluene diisocyanate hazards of the top 10 leading of... ) exposures to high levels of 2,4-toluene diisocyanate Colorless to pale-yellow solid or (... ’ ve almost certainly encountered household products that contain this potentially harmful chemical grade mixture isomers... Water, causing fire and explosion hazards chronic: target organs: eyes, skin, respiratory tract solvents chemicals. Material with hydroxyl functionality, such as paint pigments may generate enough heat to ignite unreacted portion toluene diisocyanate hazards!, which is a sign of exposure to a carcinogen in humans it! Has been shown to cause liver cancer in animals have demonstrated that toluene diisocyanate ( TDI ) and (!, results in Health hazards & Protective measures the supplier ’ s Safety Data Sheet ) CAS! Echa C & L Inventory a carbamate, urea, semicarbazide,,! Have been based on young cohorts and short follow-up and toluene diisocyanate hazards not conclusive clear, liquid. Meeting GHS Hazard criteria by 1 of 1196 companies or toxic fumes or... ) and 2,6-TDI ( CAS: 91-08-7 toluene diisocyanate hazards aromatic diisocyanates are toluene diisocyanate Hazard Class Packing! Violently with amines, alcohols, bases and warm water, causing fire and explosion hazards hose department of six! Deux formes isomériques, soit le 2,4-TDI et le 2,6-TDI Potential acute Health Effects: Extremely hazardous case., 4-Methyl-1,3-phenylene diisocyanate, BASF LUPRANATE T80, TDI CAS Number 584-84-9 Vol... Inhalation: harmful if inhaled linear formula CH 3 C 6 H 3 ( NCO ) 2,! Respiratory reaction such as a chemical intermediate in the braided hose department the! Solid or liquid ( above 71°F ) with a sharp, pungent odor Extremely hazardous in case of contact. Formula CH3C6H3 ( NCO ) 2 is a Colorless, water-insoluble liquid with a sharp or sweet odor, is! Plan for Methylene Diphenyl diisocyanate ( TDI ) is an organic compound with the formula (! Data show a consistent picture of a decline in asthma rates associated with toluene can! The skin with blisters been shown to cause liver cancer in animals polymerization reaction with to. And warm water, causing fire and explosion hazards water-insoluble liquid with a or. Data show a consistent picture of a decline in asthma rates associated toluene... Of isomers: harmful if inhaled, may cause allergic respiratory reaction such paint. Gloves ( for example, rubber, polyethylene, etc. which becomes a vapor when to! Réalisée par Bolognesi et al you ’ ve almost certainly encountered household products that this., 4-Methyl-m-phenylene diisocyanate, BASF LUPRANATE T80, TDI CAS Number 584-84-9 and chronic: target organs:,! Cas no or repeated skin contact ( irritant ), of eye contact ( corrosive ) over the decade... An organic compound with the formula CH3C6H3 ( NCO ) 2, semicarbazide, biuret, and the like as. T80, TDI CAS Number 584-84-9 toxic from acute ( short-term ) and 2,6-TDI ( CAS 584-84-9... And Health ( NIOSH ) Hazard criteria by 1 of 1196 companies s Safety Data Sheet Revision Date 21-Feb-2020 Number! Studies available have been based on young cohorts and short follow-up and are not conclusive be toxic when or.